In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neuro-inflammation, and physical changes in the hypothalamus involving microglia (the immune cells of the brain). We also review what is known about avoiding and reversing these changes.

Chapters:

00:00:00 - Introduction

00:00:37 - Brain Changes in Obesity

00:01:20 - Leptin Deficiency & Obesity

00:03:25 - Leptin Replacement

00:04:43 - Hypothalamic Obesity

00:05:42 - What is the Hypothalamus?

00:06:51 - Food Intake, Appetite, & VMH

00:08:50 - Ob Gene

00:09:34 - The Satiety Factor

00:11:11 - Leptin Paradox

00:11:51 - Leptin Resistance

00:13:41 - Leptin Physiology

00:15:03 - Leptin Resistance

00:18:11 - Effects of Leptin Resistance

00:18:29 - Improving Leptin Resistance

00:20:24 - Hypothalamic Inflammation

00:24:08 - Triggers of Hypothalamic Inflammation

00:25:45 - Fatty Acids & Hypothalamic Inflammation

00:26:24 - Advanced Glycation End Products (AGEs)

00:27:05 - Current Knowledge on Hypothalamic Inflammation

00:28:17 - Summary

00:30:16 - Outro

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References & Show Notes:

http://www.nicksterling.com/